QUOTE:

ANTECH DIAGNOSTICS, Farminghall, NY
Patient: Townsend, George Client: 7736
Animal Medical West
704 Orleans Rd., Charleston, SC 29407
Collected: 10/15/97 Reported: 10/17/97 2:18 PM
Comment: Stomach Pancreas Kidney

Biopsy (5 Sections)
Microscopic Descripton: Received for evaluation are multiple fixed tissues representing a partial
necropsy of an adult male Labrador Retriever.

Microscopically, sections of stomach are found to contain several areas of recent ulceration and hemorrhage. Adjacent mucosa is affected by mild to moderate inflammation representing infiltrates of lymphocytes and plasma cells.

Numerous prominent lymphoid mucosal modules are recognized. Some segments contain colonizing bacteria within surface crypts and mucus. The ulcerated sites are colonized by mixed bacteria.

A section of small intestine has mucosal inflammation representing infiltrates of lymphocytes and plasma cells. The lumen of one section of small intestine is filled with blood.

Sections of liver are affected by random and portal inflammation representing infiltrates of lymphocytes, plasma cells, and macrophages. Most lobules contain abundant cytoplasmic and extracellular bile pigment. Mild bile duct hyperplasia is seen in some fields. A few lobules are affected by early fibrosis. Hepatocytes are generally swollen and a few random necrotic hepatocytes are identified.

Small venules are often dilated. A section of kidney contains limited interstitial inflammation representing plasma cells and lymphocytes. Limited early fibrosis is seen in some fields. Bile casts are noted in a few tubles.

Pathological Diagnosis:
1. SEVERE ACUTE TO SUBACUTE ULCERATIVE HEMORRHAGIC GASTRITIS.
2. MODERATE CHRONIC HEPATITIS WITH SEVERE CHOLESTASIS AND MINIMAL NECROSIS.
3. MODERATE CHRONIC LYMPHOPLASMACYTIC GASTRITIS.
4. MILD CHRONIC INTERSTITIAL NEPHRITIS, KIDNEY.
5. MILD TO MODERATE LYMPHOPLASMACYTIC ENTERITIS, SMALL INTESTINE.

Comment: This dog has extensive evidence of chronic liver and gastrointestinal disease. The liver changes are non-specific, however, the presence of scattered necrotic hepatocytes suggests the possibility of a toxic pathogenesis.

Sections of pancreas and spleen contain no significant changes.